Neurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos

BACKGROUND: Exposure to the commonly used dithiocarbamate (DTC) pesticides is associated with an increased risk of developing Parkinson disease (PD), although the mechanisms by which they exert their toxicity are not completely understood. OBJECTIVE: We studied the mechanisms of ziram’s (a DTC fungi...

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Veröffentlicht in:Environ Health Perspect
Hauptverfasser: Lulla, Aaron, Barnhill, Lisa, Bitan, Gal, Ivanova, Magdalena I., Nguyen, Binh, O’Donnell, Kelley, Stahl, Mark C., Yamashiro, Chase, Klärner, Frank-Gerrit, Schrader, Thomas, Sagasti, Alvaro, Bronstein, Jeff M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Institute of Environmental Health Sciences 2016
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5089875/
https://ncbi.nlm.nih.gov/pubmed/27301718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/EHP141
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