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The molecular tweezer CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS

Mutations in superoxide dismutase 1 (SOD1) cause 15–20% of familial amyotrophic lateral sclerosis (fALS) cases. The resulting amino acid substitutions destabilize SOD1's protein structure, leading to its self-assembly into neurotoxic oligomers and aggregates, a process hypothesized to cause the...

詳細記述

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書誌詳細
出版年:J Biol Chem
主要な著者: Malik, Ravinder, Meng, Helen, Wongkongkathep, Piriya, Corrales, Christian I., Sepanj, Niki, Atlasi, Ryan S., Klärner, Frank-Gerrit, Schrader, Thomas, Spencer, Melissa J., Loo, Joseph A., Wiedau, Martina, Bitan, Gal
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416427/
https://ncbi.nlm.nih.gov/pubmed/30602569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005940
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