Inhibition of Huntingtin exon-1 aggregation by the molecular tweezer CLR01

Huntington's disease is a neurodegenerative disorder associated with the expansion of the polyglutamine tract in the exon-1 domain of the huntingtin protein (htt(e1)). Above a threshold of 37 glutamine residues, htt(e1) starts to aggregate in a nucleation-dependent manner. A 17-residue N-termin...

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Publicado no:J Am Chem Soc
Main Authors: Vöpel, Tobias, Bravo-Rodriguez, Kenny, Mittal, Sumit, Vachharajani, Shivang, Gnutt, David, Sharma, Abhishek, Steinhof, Anne, Fatoba, Oluwaseun, Ellrichmann, Gisa, Nshanian, Michael, Heid, Christian, Loo, Joseph A., Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal, Wanker, Erich E., Ebbinghaus, Simon, Sanchez-Garcia, Elsa
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5506490/
https://ncbi.nlm.nih.gov/pubmed/28406616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b11039
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