Using Molecular Tweezers to Remodel Abnormal Protein Self-Assembly and Inhibit the Toxicity of Amyloidogenic Proteins

Molecular tweezers (MTs) are broad-spectrum inhibitors of abnormal protein self-assembly, which act by binding selectively to lysine and arginine residues. Through this unique mechanism of action, MTs inhibit formation of toxic oligomers and aggregates. Their efficacy and safety have been demonstrat...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Methods Mol Biol
Autores principales: Malik, Ravinder, Di, Jing, Nair, Gayatri, Attar, Aida, Taylor, Karen, Teng, Edmond, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459406/
https://ncbi.nlm.nih.gov/pubmed/29744849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-7811-3_24
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares