Molecular Basis for Preventing α-Synuclein Aggregation by a Molecular Tweezer

Recent work on α-synuclein has shown that aggregation is controlled kinetically by the rate of reconfiguration of the unstructured chain, such that the faster the reconfiguration, the slower the aggregation. In this work we investigate this relationship by examining α-synuclein in the presence of a...

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Detalhes bibliográficos
Main Authors: Acharya, Srabasti, Safaie, Brian M., Wongkongkathep, Piriya, Ivanova, Magdalena I., Attar, Aida, Klärner, Frank-Gerrit, Schrader, Thomas, Loo, Joseph A., Bitan, Gal, Lapidus, Lisa J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036189/
https://ncbi.nlm.nih.gov/pubmed/24567327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.524520
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