Inhibition of Mutant αB Crystallin‐Induced Protein Aggregation by a Molecular Tweezer

BACKGROUND: Compromised protein quality control causes the accumulation of misfolded proteins and intracellular aggregates, contributing to cardiac disease and heart failure. The development of therapeutics directed at proteotoxicity‐based pathology in heart disease is just beginning. The molecular...

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Vydáno v:J Am Heart Assoc
Hlavní autoři: Xu, Na, Bitan, Gal, Schrader, Thomas, Klärner, Frank‐Gerrit, Osinska, Hanna, Robbins, Jeffrey
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5586456/
https://ncbi.nlm.nih.gov/pubmed/28862927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.117.006182
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