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Inhibition of Mutant αB Crystallin‐Induced Protein Aggregation by a Molecular Tweezer

BACKGROUND: Compromised protein quality control causes the accumulation of misfolded proteins and intracellular aggregates, contributing to cardiac disease and heart failure. The development of therapeutics directed at proteotoxicity‐based pathology in heart disease is just beginning. The molecular...

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Detalles Bibliográficos
Publicado en:J Am Heart Assoc
Main Authors: Xu, Na, Bitan, Gal, Schrader, Thomas, Klärner, Frank‐Gerrit, Osinska, Hanna, Robbins, Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5586456/
https://ncbi.nlm.nih.gov/pubmed/28862927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.117.006182
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