Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator

Native top-down mass spectrometry (MS) and ion mobility spectrometry were applied to characterize the interaction of a molecular tweezer assembly modulator, CLR01, with tau, a protein believed to be involved in a number of neurodegenerative disorders, including Alzheimer’s disease. The tweezer CLR01...

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Publié dans:J Am Soc Mass Spectrom
Auteurs principaux: Nshanian, Michael, Lantz, Carter, Wongkongkathep, Piriya, Schrader, Thomas, Klärner, Frank-Gerrit, Blümke, Anika, Despres, Clément, Ehrmann, Michael, Smet-Nocca, Caroline, Bitan, Gal, Loo, Joseph A.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320309/
https://ncbi.nlm.nih.gov/pubmed/30062477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-018-2027-6
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