Chemobehavioural phenomics and behaviour-based psychiatric drug discovery in the zebrafish

Por Kokel, David, Peterson, Randall T.
Publicado em 2008

Using the Zebrafish Photomotor Response for Psychotropic Drug Screening

Por Kokel, David, Peterson, Randall T.
Publicado em 2011

Discovering novel neuroactive drugs through high-throughput behavior-based chemical screening in the zebrafish

Por Bruni, Giancarlo, Lakhani, Parth, Kokel, David
Publicado em 2014

Apoptotic Cells Are Cleared by Directional Migration and elmo1-Dependent Macrophage Engulfment

Por van Ham, Tjakko J., Kokel, David, Peterson, Randall T.
Publicado em 2012

Live imaging of apoptotic cells in zebrafish

Por van Ham, Tjakko J., Mapes, James, Kokel, David, Peterson, Randall T.
Publicado em 2010

Leveraging large-scale behavioral profiling in zebrafish to explore neuroactive polypharmacology

Por McCarroll, Matthew N, Gendelev, Leo, Keiser, Michael J, Kokel, David
Publicado no ACS Chem Biol (2016)

Behavioral barcoding in the cloud: Embracing data-intensive digital phenotyping in neuropharmacology

Por Kokel, David, Rennekamp, Andrew J., Shah, Asmi H., Liebel, Urban, Peterson, Randall T.
Publicado em 2012

Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell death execution pathways downstream of ced-3 and independent of ced-9

Por Breckenridge, David G., Kang, Byung-Ho, Kokel, David, Mitani, Shohei, Staehelin, L. Andrew, Xue, Ding
Publicado em 2008

cables1 Is Required for Embryonic Neural Development: Molecular, Cellular, and Behavioral Evidence From the Zebrafish

Por GROENEWEG, JOLIJN W., WHITE, YVONNE A.R., KOKEL, DAVID, PETERSON, RANDALL T., ZUKERBERG, LAWRENCE R., BERIN, INNA, RUEDA, BO R., WOOD, ANTONY W.
Publicado em 2010

Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation

Por Rihel, Jason, Prober, David A., Arvanites, Anthony, Lam, Kelvin, Zimmerman, Steven, Jang, Sumin, Haggarty, Stephen J., Kokel, David, Rubin, Lee L., Peterson, Randall T., Schier, Alexander F.
Publicado em 2010

An In Vivo Zebrafish Screen Identifies Organophosphate Antidotes with Diverse Mechanisms of Action

Por Jin, Shan, Sarkar, Kumar S., Jin, Youngnam N., Liu, Yan, Kokel, David, Van Ham, Tjakko J., Roberts, Lee D., Gerszten, Robert E., MacRae, Calum A., Peterson, Randall T.
Publicado em 2012

Chemical Informatics and Target Identification in a Zebrafish Phenotypic Screen

Por Laggner, Christian, Kokel, David, Setola, Vincent, Tolia, Alexandra, Lin, Henry, Irwin, John J., Keiser, Michael J., Cheung, Chung Yan J., Minor, Daniel L., Roth, Bryan L., Peterson, Randall T., Shoichet, Brian K.
Publicado em 2011

Rapid behavior—based identification of neuroactive small molecules in the zebrafish

Por Kokel, David, Bryan, Jennifer, Laggner, Christian, White, Rick, Cheung, Chung Yan J., Mateus, Rita, Healey, David, Kim, Sonia, Werdich, Andreas A., Haggarty, Stephen J., MacRae, Calum A., Shoichet, Brian, Peterson, Randall T.
Publicado em 2010

Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogs Through Structure-Activity Relationship Studies

Por Dunlap, Lee E., Azinfar, Arya, Ly, Calvin, Cameron, Lindsay P., Viswanathan, Jayashri, Tombari, Robert J., Myers-Turnbull, Douglas, Taylor, Jack C., Grodzki, Ana Cristina, Lein, Pamela J., Kokel, David, Olson, David E.
Publicado no J Med Chem (2020)

Sigma-1 receptor ligands control a switch between passive and active threat responses

Por Rennekamp, Andrew J., Huang, Xi-Ping, Wang, You, Patel, Samir, Lorello, Paul J., Cade, Lindsay, Gonzales, Andrew P. W., Yeh, Jing-Ruey Joanna, Caldarone, Barbara J., Roth, Bryan L., Kokel, David, Peterson, Randall T.
Publicado no Nat Chem Biol (2016)

Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation

Por McCarroll, Matthew N., Gendelev, Leo, Kinser, Reid, Taylor, Jack, Bruni, Giancarlo, Myers-Turnbull, Douglas, Helsell, Cole, Carbajal, Amanda, Rinaldi, Capria, Kang, Hye Jin, Gong, Jung Ho, Sello, Jason K., Tomita, Susumu, Peterson, Randall T., Keiser, Michael J., Kokel, David
Publicado no Nat Commun (2019)

Photochemical activation of TRPA1 channels in neurons and animals

Por Kokel, David, Cheung, Chung Yan J., Mills, Robert, Coutinho-Budd, Jaeda, Huang, Liyi, Setola, Vincent, Sprague, Jared, Jin, Shan, Jin, Youngnam N., Huang, Xi-Ping, Bruni, Giancarlo, Woolf, Clifford, Roth, Bryan L., Hamblin, Michael R, Zylka, Mark J., Milan, David J., Peterson, Randall T.
Publicado em 2013

Identification of Nonvisual Photomotor Response Cells in the Vertebrate Hindbrain

Por Kokel, David, Dunn, Timothy W., Ahrens, Misha B., Alshut, Rüdiger, Cheung, Chung Yan J., Saint-Amant, Louis, Bruni, Giancarlo, Mateus, Rita, van Ham, Tjakko J., Shiraki, Tomoya, Fukada, Yoshitaka, Kojima, Daisuke, Yeh, Jing-Ruey J., Mikut, Ralf, von Lintig, Johannes, Engert, Florian, Peterson, Randall T.
Publicado em 2013

Zebrafish behavioral profiling identifies multi-target antipsychotic-like compounds

Por Bruni, Giancarlo, Rennekamp, Andrew J., Velenich, Andrea, McCarroll, Matthew, Gendelev, Leo, Fertsch, Ethan, Taylor, Jack, Lakhani, Parth, Lensen, Dennis, Evron, Tama, Lorello, Paul J., Huang, Xi-Ping, Kolczewski, Sabine, Carey, Galen, Caldarone, Barbara J., Prinssen, Eric, Roth, Bryan L., Keiser, Michael J., Peterson, Randall T., Kokel, David
Publicado no Nat Chem Biol (2016)

A Non-Hallucinogenic Psychedelic Analog with Therapeutic Potential

Por Cameron, Lindsay P., Tombari, Robert J., Lu, Ju, Pell, Alexander J., Hurley, Zefan Q., Ehinger, Yann, Vargas, Maxemiliano V., McCarroll, Matthew N., Taylor, Jack C., Myers-Turnbull, Douglas, Liu, Taohui, Yaghoobi, Bianca, Laskowski, Lauren J., Anderson, Emilie I., Zhang, Guoliang, Viswanathan, Jayashri, Brown, Brandon M., Tjia, Michelle, Dunlap, Lee E., Rabow, Zachary T., Fiehn, Oliver, Wulff, Heike, McCorvy, John D., Lein, Pamela J., Kokel, David, Ron, Dorit, Peters, Jamie, Zuo, Yi, Olson, David E.
Publicado no Nature (2020)