Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation

Anesthetics are generally associated with sedation, but some anesthetics can also increase brain and motor activity—a phenomenon known as paradoxical excitation. Previous studies have identified GABA(A) receptors as the primary targets of most anesthetic drugs, but how these compounds produce parado...

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Pubblicato in:Nat Commun
Autori principali: McCarroll, Matthew N., Gendelev, Leo, Kinser, Reid, Taylor, Jack, Bruni, Giancarlo, Myers-Turnbull, Douglas, Helsell, Cole, Carbajal, Amanda, Rinaldi, Capria, Kang, Hye Jin, Gong, Jung Ho, Sello, Jason K., Tomita, Susumu, Peterson, Randall T., Keiser, Michael J., Kokel, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6733874/
https://ncbi.nlm.nih.gov/pubmed/31501447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11936-w
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