Sedation and Anesthesia Mediated by Distinct GABA(A) Receptor Isoforms

The specific mechanisms underlying general anesthesia are primarily unknown. The intravenous general anesthetic etomidate acts by potentiating GABA(A) receptors, with selectivity for β2 and β3 subunit-containing receptors determined by a single asparagine residue. We generated a genetically modified...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Reynolds, David S., Rosahl, Thomas W., Cirone, Jennifer, O'Meara, Gillian F., Haythornthwaite, Alison, Newman, Richard J., Myers, Janice, Sur, Cyrille, Howell, Owain, Rutter, A. Richard, Atack, John, Macaulay, Alison J., Hadingham, Karen L., Hutson, Peter H., Belelli, Delia, Lambert, Jeremy J., Dawson, Gerard R., McKernan, Ruth, Whiting, Paul J., Wafford, Keith A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2003
Assuntos:
Cellular/Molecular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740367/
https://ncbi.nlm.nih.gov/pubmed/13679430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-24-08608.2003
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