Sedation and Anesthesia Mediated by Distinct GABA(A) Receptor Isoforms

The specific mechanisms underlying general anesthesia are primarily unknown. The intravenous general anesthetic etomidate acts by potentiating GABA(A) receptors, with selectivity for β2 and β3 subunit-containing receptors determined by a single asparagine residue. We generated a genetically modified...

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Bibliografske podrobnosti
izdano v:J Neurosci
Main Authors: Reynolds, David S., Rosahl, Thomas W., Cirone, Jennifer, O'Meara, Gillian F., Haythornthwaite, Alison, Newman, Richard J., Myers, Janice, Sur, Cyrille, Howell, Owain, Rutter, A. Richard, Atack, John, Macaulay, Alison J., Hadingham, Karen L., Hutson, Peter H., Belelli, Delia, Lambert, Jeremy J., Dawson, Gerard R., McKernan, Ruth, Whiting, Paul J., Wafford, Keith A.
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2003
Teme:
Cellular/Molecular
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740367/
https://ncbi.nlm.nih.gov/pubmed/13679430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-24-08608.2003
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