Sedation and Anesthesia Mediated by Distinct GABA(A) Receptor Isoforms

The specific mechanisms underlying general anesthesia are primarily unknown. The intravenous general anesthetic etomidate acts by potentiating GABA(A) receptors, with selectivity for β2 and β3 subunit-containing receptors determined by a single asparagine residue. We generated a genetically modified...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Reynolds, David S., Rosahl, Thomas W., Cirone, Jennifer, O'Meara, Gillian F., Haythornthwaite, Alison, Newman, Richard J., Myers, Janice, Sur, Cyrille, Howell, Owain, Rutter, A. Richard, Atack, John, Macaulay, Alison J., Hadingham, Karen L., Hutson, Peter H., Belelli, Delia, Lambert, Jeremy J., Dawson, Gerard R., McKernan, Ruth, Whiting, Paul J., Wafford, Keith A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2003
Schlagworte:
Cellular/Molecular
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740367/
https://ncbi.nlm.nih.gov/pubmed/13679430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-24-08608.2003
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