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Discovering novel neuroactive drugs through high-throughput behavior-based chemical screening in the zebrafish

Most neuroactive drugs were discovered through unexpected behavioral observations. Systematic behavioral screening is inefficient in most model organisms. But, automated technologies are enabling a new phase of discovery-based research in central nervous system (CNS) pharmacology. Researchers are us...

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Detalles Bibliográficos
Autores principales: Bruni, Giancarlo, Lakhani, Parth, Kokel, David
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109429/
https://ncbi.nlm.nih.gov/pubmed/25104936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2014.00153
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