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Rapid behavior—based identification of neuroactive small molecules in the zebrafish

Neuroactive small molecules are indispensable tools for treating mental illnesses and dissecting nervous system function. However, it has been difficult to discover novel neuroactive drugs. Here, we describe a high—throughput (HT) behavior—based approach to neuroactive small molecule discovery in th...

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Detalhes bibliográficos
Main Authors: Kokel, David, Bryan, Jennifer, Laggner, Christian, White, Rick, Cheung, Chung Yan J., Mateus, Rita, Healey, David, Kim, Sonia, Werdich, Andreas A., Haggarty, Stephen J., MacRae, Calum A., Shoichet, Brian, Peterson, Randall T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834185/
https://ncbi.nlm.nih.gov/pubmed/20081854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.307
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