Chemical Informatics and Target Identification in a Zebrafish Phenotypic Screen

Target identification is a core challenge in chemical genetics. Here we use chemical similarity to predict computationally the targets of 586 compounds active in a zebrafish behavioral assay. Of 20 predictions tested, 11 had activities ranging from 1 to 10,000nM on the predicted targets. The role of...

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Detalhes bibliográficos
Main Authors: Laggner, Christian, Kokel, David, Setola, Vincent, Tolia, Alexandra, Lin, Henry, Irwin, John J., Keiser, Michael J., Cheung, Chung Yan J., Minor, Daniel L., Roth, Bryan L., Peterson, Randall T., Shoichet, Brian K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262069/
https://ncbi.nlm.nih.gov/pubmed/22179068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.732
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