Testing Tuberculosis Drug Efficacy in a Zebrafish High-Throughput Translational Medicine Screen

The translational value of zebrafish high-throughput screens can be improved when more knowledge is available on uptake characteristics of potential drugs. We investigated reference antibiotics and 15 preclinical compounds in a translational zebrafish-rodent screening system for tuberculosis. As a m...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Ordas, Anita, Raterink, Robert-Jan, Cunningham, Fraser, Jansen, Hans J., Wiweger, Malgorzata I., Jong-Raadsen, Susanne, Bos, Sabine, Bates, Robert H., Barros, David, Meijer, Annemarie H., Vreeken, Rob J., Ballell-Pages, Lluís, Dirks, Ron P., Hankemeier, Thomas, Spaink, Herman P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2015
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335901/
https://ncbi.nlm.nih.gov/pubmed/25385118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03588-14
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