Trafficking and Quality Control of the Gonadotropin Releasing Hormone Receptor in Health and Disease

Por Conn, P. Michael, Janovick, Jo Ann
Publicado em 2008

Salt bridge integrates GPCR activation with protein trafficking

Por Janovick, Jo Ann, Conn, P. Michael
Publicado em 2010

Pharmacoperone Identification for Therapeutic Rescue of Misfolded Mutant Proteins

Por Conn, P. Michael, Janovick, Jo Ann
Publicado em 2011

Therapeutic Rescue of Misfolded Mutants: Validation of Primary High Throughput Screens for Identification of Pharmacoperone Drugs

Por Janovick, Jo Ann, Park, Byung S., Conn, P. Michael
Publicado em 2011

Species sequence differences determine the interaction of GnRH receptor with the cellular quality control system

Por Cabrera-Wrooman, Alejandro, Janovick, Jo Ann, Conn, P. Michael
Publicado em 2013

Assay strategies for identification of therapeutic leads that target protein trafficking

Por Conn, P. Michael, Spicer, Timothy P., Scampavia, Louis, Janovick, Jo Ann
Publicado no Trends Pharmacol Sci (2015)

Salt Bridges Overlapping the Gonadotropin-Releasing Hormone Receptor Agonist Binding Site Reveal a Coincidence Detector for G Protein-Coupled Receptor Activation

Por Janovick, Jo Ann, Pogozheva, Irina D., Mosberg, Henry I., Conn, P. Michael
Publicado em 2011

High Throughput Screen for Pharmacoperones of the Vasopressin Type 2 Receptor

Por Conn, P. Michael, Smith, Emery, Hodder, Peter, Janovick, Jo Ann, Smithson, David C.
Publicado em 2013

Rescue of Misrouted GnRHR Mutants Reveals Its Constitutive Activity

Por Janovick, Jo Ann, Pogozheva, Irina D., Mosberg, Henry I., Cornea, Anda, Conn, P. Michael
Publicado em 2012

A Phenotypic High Throughput Screening Assay for the Identification of Pharmacoperones for the Gonadotropin Releasing Hormone Receptor

Por Conn, P. Michael, Smith, Emery, Spicer, Timothy, Chase, Peter, Scampavia, Louis, Janovick, Jo Ann
Publicado em 2014

Structure-Activity Relationship Studies of Gonadotropin Releasing Hormone Antagonists Containing S-aryl/alkyl Norcysteines and their Oxidized Derivatives

Por Samant, Manoj P., White, Richard, Hong, Doley J., Croston, Glenn, Conn, P. Michael, Janovick, Jo Ann, Rivier, Jean
Publicado em 2007

Receptor Antagonism/Agonism Can Be Uncoupled from Pharmacoperone Activity

Por Janovick, Jo Ann, Spicer, Timothy P., Smith, Emery, Bannister, Thomas D., Kenakin, Terry, Scampavia, Louis, Conn, P. Michael
Publicado no Mol Cell Endocrinol (2016)

Increased Plasma Membrane Expression of Human Follicle-Stimulating Hormone Receptor by a Small Molecule Thienopyr(im)idine

Por Janovick, Jo Ann, Maya-Núñez, Guadalupe, Ulloa-Aguirre, Alfredo, Huhtaniemi, Ilpo T., Dias, James A., Verbost, Pieter, Conn, P. Michael
Publicado em 2008

Molecular Mechanism of Action of Pharmacoperone Rescue of Misrouted GPCR Mutants: The GnRH Receptor

Por Janovick, Jo Ann, Patny, Akshay, Mosley, Ralph, Goulet, Mark T., Altman, Michael D., Rush, Thomas S., Cornea, Anda, Conn, P. Michael
Publicado em 2009

Transitioning Pharmacoperones to Therapeutic Use: In Vivo Proof-of-Principle and Design of High Throughput Screens

Por Conn, P. Michael, Smithson, David C., Hodder, Peter S., Stewart, M. David, Behringer, Richard R., Smith, Emery, Ulloa-Aguirre, Alfredo, Janovick, Jo Ann
Publicado em 2013

Biochemical Mechanism of Pathogenesis of Human Gonadotropin-Releasing Hormone Receptor Mutants Thr104Ile and Tyr108Cys Associated With Familial Hypogonadotropic Hypogonadism

Por Maya-Núñez, Guadalupe, Janovick, Jo Ann, Aguilar-Rojas, Arturo, Jardón-Valadez, Eduardo, Leaños-Miranda, Alfredo, Zariñan, Teresa, Ulloa-Aguirre, Alfredo, Conn, P. Michael
Publicado em 2011

REFOLDING OF MISFOLDED MUTANT GPCR: POST-TRANSLATIONAL PHARMACOPERONE ACTION IN VITRO

Por Janovick, Jo Ann, Brothers, Shaun P., Cornea, Anda, Bush, Eugene, Goulet, Mark T., Ashton, Wallace T., Sauer, Daryl R., Haviv, Fortuna, Greer, Jonathan, Conn, P. Michael
Publicado em 2007

Quality control autophagy degrades soluble ERAD-resistant conformers of the misfolded membrane protein GnRHR

Por Houck, Scott A., Ren, Hong Yu, Madden, Victoria J., Bonner, Jacob N., Conlin, Michael P., Janovick, Jo Ann, Conn, P. Michael, Cyr, Douglas M.
Publicado em 2014

Mice Harboring Gnrhr E90K, a Mutation that Causes Protein Misfolding and Hypogonadotropic Hypogonadism in Humans, Exhibit Testis Size Reduction and Ovulation Failure

Por Stewart, M. David, Deng, Jian Ming, Stewart, C. Allison, Mullen, Rachael D., Wang, Ying, Lopez, Suhujey, Serna, M. Katalina, Huang, Cheng-Chiu, Janovick, Jo Ann, Pask, Andrew J., Schwartz, Robert J., Conn, P. Michael, Behringer, Richard R.
Publicado em 2012

Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy

Por Janovick, Jo Ann, Stewart, M. David, Jacob, Darla, Martin, L. D., Deng, Jian Min, Stewart, C. Allison, Wang, Ying, Cornea, Anda, Chavali, Lakshmi, Lopez, Suhujey, Mitalipov, Shoukhrat, Kang, Eunju, Lee, Hyo-Sang, Manna, Pulak R., Stocco, Douglas M., Behringer, Richard R., Conn, P. Michael
Publicado em 2013