Trafficking and Quality Control of the Gonadotropin Releasing Hormone Receptor in Health and Disease

Yazar: Conn, P. Michael, Janovick, Jo Ann
Baskı/Yayın Bilgisi 2008

Salt bridge integrates GPCR activation with protein trafficking

Yazar: Janovick, Jo Ann, Conn, P. Michael
Baskı/Yayın Bilgisi 2010

Pharmacoperone Identification for Therapeutic Rescue of Misfolded Mutant Proteins

Yazar: Conn, P. Michael, Janovick, Jo Ann
Baskı/Yayın Bilgisi 2011

Therapeutic Rescue of Misfolded Mutants: Validation of Primary High Throughput Screens for Identification of Pharmacoperone Drugs

Yazar: Janovick, Jo Ann, Park, Byung S., Conn, P. Michael
Baskı/Yayın Bilgisi 2011

Species sequence differences determine the interaction of GnRH receptor with the cellular quality control system

Yazar: Cabrera-Wrooman, Alejandro, Janovick, Jo Ann, Conn, P. Michael
Baskı/Yayın Bilgisi 2013

Assay strategies for identification of therapeutic leads that target protein trafficking

Yazar: Conn, P. Michael, Spicer, Timothy P., Scampavia, Louis, Janovick, Jo Ann
Yayımlandı Trends Pharmacol Sci (2015)

Salt Bridges Overlapping the Gonadotropin-Releasing Hormone Receptor Agonist Binding Site Reveal a Coincidence Detector for G Protein-Coupled Receptor Activation

Yazar: Janovick, Jo Ann, Pogozheva, Irina D., Mosberg, Henry I., Conn, P. Michael
Baskı/Yayın Bilgisi 2011

High Throughput Screen for Pharmacoperones of the Vasopressin Type 2 Receptor

Yazar: Conn, P. Michael, Smith, Emery, Hodder, Peter, Janovick, Jo Ann, Smithson, David C.
Baskı/Yayın Bilgisi 2013

Rescue of Misrouted GnRHR Mutants Reveals Its Constitutive Activity

Yazar: Janovick, Jo Ann, Pogozheva, Irina D., Mosberg, Henry I., Cornea, Anda, Conn, P. Michael
Baskı/Yayın Bilgisi 2012

A Phenotypic High Throughput Screening Assay for the Identification of Pharmacoperones for the Gonadotropin Releasing Hormone Receptor

Yazar: Conn, P. Michael, Smith, Emery, Spicer, Timothy, Chase, Peter, Scampavia, Louis, Janovick, Jo Ann
Baskı/Yayın Bilgisi 2014

Pharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias

Yazar: Janovick, Jo Ann, Spicer, Timothy P., Bannister, Thomas D., Scampavia, Louis, Conn, P. Michael
Yayımlandı PLoS One (2017)

Rescue of mutant gonadotropin-releasing hormone receptor function independent of cognate receptor activity

Yazar: Smith, Emery, Janovick, Jo Ann, Bannister, Thomas D., Shumate, Justin, Ganapathy, Vadivel, Scampavia, Louis, Spicer, Timothy P.
Yayımlandı Sci Rep (2020)

Structure-Activity Relationship Studies of Gonadotropin Releasing Hormone Antagonists Containing S-aryl/alkyl Norcysteines and their Oxidized Derivatives

Yazar: Samant, Manoj P., White, Richard, Hong, Doley J., Croston, Glenn, Conn, P. Michael, Janovick, Jo Ann, Rivier, Jean
Baskı/Yayın Bilgisi 2007

Receptor Antagonism/Agonism Can Be Uncoupled from Pharmacoperone Activity

Yazar: Janovick, Jo Ann, Spicer, Timothy P., Smith, Emery, Bannister, Thomas D., Kenakin, Terry, Scampavia, Louis, Conn, P. Michael
Yayımlandı Mol Cell Endocrinol (2016)

Identification of Potential Pharmacoperones Capable of Rescuing the Functionality of Misfolded Vasopressin 2 Receptor Involved in Nephrogenic Diabetes Insipidus

Yazar: Smith, Emery, Janovick, Jo Ann, Bannister, Thomas D., Shumate, Justin, Scampavia, Louis, Conn, P. Michael, Spicer, Timothy P.
Yayımlandı J Biomol Screen (2016)

Increased Plasma Membrane Expression of Human Follicle-Stimulating Hormone Receptor by a Small Molecule Thienopyr(im)idine

Yazar: Janovick, Jo Ann, Maya-Núñez, Guadalupe, Ulloa-Aguirre, Alfredo, Huhtaniemi, Ilpo T., Dias, James A., Verbost, Pieter, Conn, P. Michael
Baskı/Yayın Bilgisi 2008

Molecular Mechanism of Action of Pharmacoperone Rescue of Misrouted GPCR Mutants: The GnRH Receptor

Yazar: Janovick, Jo Ann, Patny, Akshay, Mosley, Ralph, Goulet, Mark T., Altman, Michael D., Rush, Thomas S., Cornea, Anda, Conn, P. Michael
Baskı/Yayın Bilgisi 2009

Transitioning Pharmacoperones to Therapeutic Use: In Vivo Proof-of-Principle and Design of High Throughput Screens

Yazar: Conn, P. Michael, Smithson, David C., Hodder, Peter S., Stewart, M. David, Behringer, Richard R., Smith, Emery, Ulloa-Aguirre, Alfredo, Janovick, Jo Ann
Baskı/Yayın Bilgisi 2013

Biochemical Mechanism of Pathogenesis of Human Gonadotropin-Releasing Hormone Receptor Mutants Thr104Ile and Tyr108Cys Associated With Familial Hypogonadotropic Hypogonadism

Yazar: Maya-Núñez, Guadalupe, Janovick, Jo Ann, Aguilar-Rojas, Arturo, Jardón-Valadez, Eduardo, Leaños-Miranda, Alfredo, Zariñan, Teresa, Ulloa-Aguirre, Alfredo, Conn, P. Michael
Baskı/Yayın Bilgisi 2011

REFOLDING OF MISFOLDED MUTANT GPCR: POST-TRANSLATIONAL PHARMACOPERONE ACTION IN VITRO

Yazar: Janovick, Jo Ann, Brothers, Shaun P., Cornea, Anda, Bush, Eugene, Goulet, Mark T., Ashton, Wallace T., Sauer, Daryl R., Haviv, Fortuna, Greer, Jonathan, Conn, P. Michael
Baskı/Yayın Bilgisi 2007