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Identification of Potential Pharmacoperones Capable of Rescuing the Functionality of Misfolded Vasopressin 2 Receptor Involved in Nephrogenic Diabetes Insipidus
Pharmacoperones correct the folding of otherwise misfolded protein mutants, restoring function (i.e. providing “rescue”) by correcting their trafficking. Currently most pharmacoperones possess intrinsic antagonist activity because they were identified using methods initially aimed at discovering suc...
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| Publicado no: | J Biomol Screen |
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| Principais autores: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5594746/ https://ncbi.nlm.nih.gov/pubmed/27280550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057116653925 |
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