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Receptor Antagonism/Agonism Can Be Uncoupled from Pharmacoperone Activity
Pharmacoperones rescue misrouted mutants of the vasopressin receptor type 2 (V2R) and enable them to traffic to the correct biological locus where they function. Previously, a library of nearly 645,000 structures was interrogated with a high throughput screen; pharmacoperones were identified for V2R...
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| Опубликовано в: : | Mol Cell Endocrinol |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4983495/ https://ncbi.nlm.nih.gov/pubmed/27389877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2016.07.003 |
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