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Receptor Antagonism/Agonism Can Be Uncoupled from Pharmacoperone Activity

Pharmacoperones rescue misrouted mutants of the vasopressin receptor type 2 (V2R) and enable them to traffic to the correct biological locus where they function. Previously, a library of nearly 645,000 structures was interrogated with a high throughput screen; pharmacoperones were identified for V2R...

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Detalles Bibliográficos
Publicado en:Mol Cell Endocrinol
Main Authors: Janovick, Jo Ann, Spicer, Timothy P., Smith, Emery, Bannister, Thomas D., Kenakin, Terry, Scampavia, Louis, Conn, P. Michael
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983495/
https://ncbi.nlm.nih.gov/pubmed/27389877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2016.07.003
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