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Assay strategies for identification of therapeutic leads that target protein trafficking
Receptors, enzymes and ion channels are traditional targets of therapeutic development. A common strategy is to target these proteins with agents that either activate or suppress their activity with ligands or substrates that occupy orthosteric sites or have allosteric interactions. An alternative a...
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| Pubblicato in: | Trends Pharmacol Sci |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4532603/ https://ncbi.nlm.nih.gov/pubmed/26067100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2015.05.004 |
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