Rescue of Misrouted GnRHR Mutants Reveals Its Constitutive Activity

G protein-coupled receptors (GPCR) play central roles in almost all physiological functions, and mutations in GPCR are responsible for over 30 hereditary diseases associated with loss or gain of receptor function. Gain of function mutants are frequently described as having constitutive activity (CA)...

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Detalhes bibliográficos
Principais autores: Janovick, Jo Ann, Pogozheva, Irina D., Mosberg, Henry I., Cornea, Anda, Conn, P. Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2012
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3385788/
https://ncbi.nlm.nih.gov/pubmed/22595961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1089
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