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Rescue of Misrouted GnRHR Mutants Reveals Its Constitutive Activity

G protein-coupled receptors (GPCR) play central roles in almost all physiological functions, and mutations in GPCR are responsible for over 30 hereditary diseases associated with loss or gain of receptor function. Gain of function mutants are frequently described as having constitutive activity (CA)...

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Détails bibliographiques
Auteurs principaux: Janovick, Jo Ann, Pogozheva, Irina D., Mosberg, Henry I., Cornea, Anda, Conn, P. Michael
Format: Artigo
Langue:Inglês
Publié: Endocrine Society 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3385788/
https://ncbi.nlm.nih.gov/pubmed/22595961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1089
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