Quality control autophagy degrades soluble ERAD-resistant conformers of the misfolded membrane protein GnRHR

Molecular chaperones triage misfolded proteins via action as substrate selectors for quality control (QC) machines that fold or degrade clients. Herein, the endoplasmic reticulum (ER) associated Hsp40 JB12 is reported to participate in partitioning mutant conformers of GnRHR, a G-protein coupled rec...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Houck, Scott A., Ren, Hong Yu, Madden, Victoria J., Bonner, Jacob N., Conlin, Michael P., Janovick, Jo Ann, Conn, P. Michael, Cyr, Douglas M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070183/
https://ncbi.nlm.nih.gov/pubmed/24685158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.02.025
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