Quality control autophagy degrades soluble ERAD-resistant conformers of the misfolded membrane protein GnRHR

Molecular chaperones triage misfolded proteins via action as substrate selectors for quality control (QC) machines that fold or degrade clients. Herein, the endoplasmic reticulum (ER) associated Hsp40 JB12 is reported to participate in partitioning mutant conformers of GnRHR, a G-protein coupled rec...

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Detalhes bibliográficos
Main Authors: Houck, Scott A., Ren, Hong Yu, Madden, Victoria J., Bonner, Jacob N., Conlin, Michael P., Janovick, Jo Ann, Conn, P. Michael, Cyr, Douglas M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070183/
https://ncbi.nlm.nih.gov/pubmed/24685158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.02.025
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