Salt Bridges Overlapping the Gonadotropin-Releasing Hormone Receptor Agonist Binding Site Reveal a Coincidence Detector for G Protein-Coupled Receptor Activation

G protein-coupled receptors (GPCRs) play central roles in most physiological functions, and mutations in them cause heritable diseases. Whereas crystal structures provide details about the structure of GPCRs, there is little information that identifies structural features that permit receptors to pa...

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Detaylı Bibliyografya
Asıl Yazarlar: Janovick, Jo Ann, Pogozheva, Irina D., Mosberg, Henry I., Conn, P. Michael
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2011
Konular:
Cellular and Molecular
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141895/
https://ncbi.nlm.nih.gov/pubmed/21527534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.180869
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