Salt Bridges Overlapping the Gonadotropin-Releasing Hormone Receptor Agonist Binding Site Reveal a Coincidence Detector for G Protein-Coupled Receptor Activation

G protein-coupled receptors (GPCRs) play central roles in most physiological functions, and mutations in them cause heritable diseases. Whereas crystal structures provide details about the structure of GPCRs, there is little information that identifies structural features that permit receptors to pa...

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Главные авторы: Janovick, Jo Ann, Pogozheva, Irina D., Mosberg, Henry I., Conn, P. Michael
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2011
Предметы:
Cellular and Molecular
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141895/
https://ncbi.nlm.nih.gov/pubmed/21527534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.180869
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