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Rescue of mutant gonadotropin-releasing hormone receptor function independent of cognate receptor activity
Molecules that correct the folding of protein mutants, restoring their functional trafficking, are called pharmacoperones. Most are clinically irrelevant and possess intrinsic antagonist or agonist activity. Here, we identify compounds capable of rescuing the activity of mutant gonadotropin-releasin...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7324376/ https://ncbi.nlm.nih.gov/pubmed/32601341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67473-w |
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