REFOLDING OF MISFOLDED MUTANT GPCR: POST-TRANSLATIONAL PHARMACOPERONE ACTION IN VITRO

All reported GnRH receptor mutants (causing human hypogonadotropic hypogonadism) are misfolded proteins that cannot traffic to the plasma membrane. Pharmacoperones correct mis-folding and rescue mutants, routing them to the plasma membrane where they regain function. Because pharmacoperones are ofte...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Janovick, Jo Ann, Brothers, Shaun P., Cornea, Anda, Bush, Eugene, Goulet, Mark T., Ashton, Wallace T., Sauer, Daryl R., Haviv, Fortuna, Greer, Jonathan, Conn, P. Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169380/
https://ncbi.nlm.nih.gov/pubmed/17555869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2007.04.012
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados