MORPHEEINS – A NEW PATHWAY FOR ALLOSTERIC DRUG DISCOVERY

Por JAFFE, EILEEN K.
Publicado em 2010

Impact of Quaternary Structure Dynamics on Allosteric Drug Discovery

Por Jaffe, Eileen K.
Publicado em 2013

The Remarkable Character of Porphobilinogen Synthase

Por Jaffe, Eileen K.
Publicado no Acc Chem Res (2016)

New Protein Structures Provide an Updated Understanding of Phenylketonuria

Por Jaffe, Eileen K.
Publicado no Mol Genet Metab (2017)

ALAD Porphyria Is a Conformational Disease

Por Jaffe, Eileen K. , Stith, Linda 
Publicado em 2007

Dynamic dissociating homo-oligomers and the control of protein function

Por Selwood, Trevor, Jaffe, Eileen K.
Publicado em 2011

Expanding the Concepts in Protein Structure-Function Relationships and Enzyme Kinetics: Teaching using Morpheeins

Por Lawrence, Sarah H., Jaffe, Eileen K.
Publicado em 2008

The morpheein model of allostery: Evaluating proteins as potential morpheeins

Por Jaffe, Eileen K., Lawrence, Sarah H.
Publicado em 2012

Allostery and the dynamic oligomerization of porphobilinogen synthase

Por Jaffe, Eileen K., Lawrence, Sarah H.
Publicado em 2011

Diverse clinical compounds alter the quaternary structure and inhibit the activity of an essential enzyme

Por Lawrence, Sarah H., Selwood, Trevor, Jaffe, Eileen K.
Publicado em 2011

Environmental contaminants perturb fragile protein assemblies and inhibit normal protein function

Por Lawrence, Sarah H., Selwood, Trevor, Jaffe, Eileen K.
Publicado em 2013

Docking to large allosteric binding sites on protein surfaces

Por Ramirez, Ursula D., Myachina, Faina, Stith, Linda, Jaffe, Eileen K.
Publicado em 2010

Plastid-associated Porphobilinogen Synthase from Toxoplasma gondii: KINETIC AND STRUCTURAL PROPERTIES VALIDATE THERAPEUTIC POTENTIAL

Por Shanmugam, Dhanasekaran, Wu, Bo, Ramirez, Ursula, Jaffe, Eileen K., Roos, David S.
Publicado em 2010

Facile Synthesis of Mutagen X (MX): 3-Chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one

Por Velvadapu, Venkata, McDonnell, Mark E., Jaffe, Eileen K., Reitz, Allen B.
Publicado em 2012

Allosteric Inhibition of Human Porphobilinogen Synthase

Por Lawrence, Sarah H., Ramirez, Ursula D., Selwood, Trevor, Stith, Linda, Jaffe, Eileen K.
Publicado em 2009

A New Model for Allosteric Regulation of Phenylalanine Hydroxylase: Implications for Disease and Therapeutics

Por Jaffe, Eileen K, Stith, Linda, Lawrence, Sarah H., Andrake, Mark, Dunbrack, Roland L.
Publicado em 2013

Probing the Oligomeric Assemblies of Pea Porphobilinogen Synthase by Analytical Ultracentrifugation

Por Kokona, Bashkim, Rigotti, Daniel J., Wasson, Andrew S., Lawrence, Sarah H., Jaffe, Eileen K., Fairman, Robert
Publicado em 2008

Pseudomonas aeruginosa porphobilinogen synthase assembly state regulators: hit discovery and initial SAR studies

Por Reitz, Allen B., Ramirez, Ursula D., Stith, Linda, Du, Yanming, Smith, Garry R., Jaffe, Eileen K.
Publicado em 2010

Rhodobacter capsulatus porphobilinogen synthase, a high activity metal ion independent hexamer

Por Bollivar, David W, Clauson, Cheryl, Lighthall, Rachel, Forbes, Siiri, Kokona, Bashkim, Fairman, Robert, Kundrat, Lenka, Jaffe, Eileen K
Publicado em 2004

Shape shifting leads to small molecule allosteric drug discovery

Por Lawrence, Sarah H., Ramirez, Ursula D., Tang, Lei, Fazliyev, Farit, Kundrat, Lenka, Markham, George D., Jaffe, Eileen K.
Publicado em 2008