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Diverse clinical compounds alter the quaternary structure and inhibit the activity of an essential enzyme

An in vitro evaluation of the Johns Hopkins Clinical Compound Library demonstrates that certain drugs can alter the quaternary structure of an essential human protein. Human porphobilinogen synthase (HsPBGS) is an essential enzyme involved in heme biosynthesis; it exists as an equilibrium of high ac...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lawrence, Sarah H., Selwood, Trevor, Jaffe, Eileen K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3236527/
https://ncbi.nlm.nih.gov/pubmed/21506274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201100009
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