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Diverse clinical compounds alter the quaternary structure and inhibit the activity of an essential enzyme
An in vitro evaluation of the Johns Hopkins Clinical Compound Library demonstrates that certain drugs can alter the quaternary structure of an essential human protein. Human porphobilinogen synthase (HsPBGS) is an essential enzyme involved in heme biosynthesis; it exists as an equilibrium of high ac...
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| Main Authors: | , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2011
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3236527/ https://ncbi.nlm.nih.gov/pubmed/21506274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201100009 |
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