Allosteric Inhibition of Human Porphobilinogen Synthase

Porphobilinogen synthase (PBGS) catalyzes the first common step in tetrapyrrole (e.g. heme, chlorophyll) biosynthesis. Human PBGS exists as an equilibrium of high activity octamers, low activity hexamers, and alternate dimer configurations that dictate the stoichiometry and architecture of further a...

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Bibliografski detalji
Glavni autori: Lawrence, Sarah H., Ramirez, Ursula D., Selwood, Trevor, Stith, Linda, Jaffe, Eileen K.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Enzyme Catalysis and Regulation
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791010/
https://ncbi.nlm.nih.gov/pubmed/19812033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.026294
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