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Allosteric Inhibition of Human Porphobilinogen Synthase

Porphobilinogen synthase (PBGS) catalyzes the first common step in tetrapyrrole (e.g. heme, chlorophyll) biosynthesis. Human PBGS exists as an equilibrium of high activity octamers, low activity hexamers, and alternate dimer configurations that dictate the stoichiometry and architecture of further a...

詳細記述

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書誌詳細
主要な著者: Lawrence, Sarah H., Ramirez, Ursula D., Selwood, Trevor, Stith, Linda, Jaffe, Eileen K.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791010/
https://ncbi.nlm.nih.gov/pubmed/19812033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.026294
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