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Allostery and the dynamic oligomerization of porphobilinogen synthase

The structural basis for allosteric regulation of porphobilinogen synthase (PBGS) is modulation of a quaternary structure equilibrium between octamer and hexamer (via dimers), which is represented schematically as 8mer ⇔ 2mer ⇔ 2mer* ⇔ 6mer*. The “*” represents a reorientation between two domains of...

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Hlavní autoři: Jaffe, Eileen K., Lawrence, Sarah H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291741/
https://ncbi.nlm.nih.gov/pubmed/22037356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2011.10.010
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