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Allostery and the dynamic oligomerization of porphobilinogen synthase
The structural basis for allosteric regulation of porphobilinogen synthase (PBGS) is modulation of a quaternary structure equilibrium between octamer and hexamer (via dimers), which is represented schematically as 8mer ⇔ 2mer ⇔ 2mer* ⇔ 6mer*. The “*” represents a reorientation between two domains of...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3291741/ https://ncbi.nlm.nih.gov/pubmed/22037356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2011.10.010 |
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