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Pseudomonas aeruginosa porphobilinogen synthase assembly state regulators: hit discovery and initial SAR studies

Porphobilinogen synthase (PBGS) catalyzes the first common step in the biosynthesis of the essential heme, chlorophyll and vitamin B(12) heme pigments. PBGS activity is regulated by assembly state, with certain oligomers exhibiting biological activity and others either partially or completely inacti...

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Autori principali: Reitz, Allen B., Ramirez, Ursula D., Stith, Linda, Du, Yanming, Smith, Garry R., Jaffe, Eileen K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3106444/
https://ncbi.nlm.nih.gov/pubmed/21643541
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