Allosteric Inhibition of Human Porphobilinogen Synthase

Porphobilinogen synthase (PBGS) catalyzes the first common step in tetrapyrrole (e.g. heme, chlorophyll) biosynthesis. Human PBGS exists as an equilibrium of high activity octamers, low activity hexamers, and alternate dimer configurations that dictate the stoichiometry and architecture of further a...

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Detaylı Bibliyografya
Asıl Yazarlar: Lawrence, Sarah H., Ramirez, Ursula D., Selwood, Trevor, Stith, Linda, Jaffe, Eileen K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2009
Konular:
Enzyme Catalysis and Regulation
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791010/
https://ncbi.nlm.nih.gov/pubmed/19812033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.026294
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