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Impact of Quaternary Structure Dynamics on Allosteric Drug Discovery

The morpheein model of allosteric regulation draws attention to proteins that can exist as an equilibrium of functionally distinct assemblies where: one subunit conformation assembles into one multimer; a different subunit conformation assembles into a different multimer; and the various multimers a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser: Jaffe, Eileen K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631351/
https://ncbi.nlm.nih.gov/pubmed/23409765
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