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A New Model for Allosteric Regulation of Phenylalanine Hydroxylase: Implications for Disease and Therapeutics
The structural basis for allosteric regulation of phenylalanine hydroxylase (PAH), whose dysfunction causes phenylketonuria (PKU), is poorly understood. A new morpheein model for PAH allostery is proposed to consist of a dissociative equilibrium between two architecturally different tetramers whose...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3580015/ https://ncbi.nlm.nih.gov/pubmed/23296088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2012.12.017 |
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