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First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer
Improved understanding of the relationship among structure, dynamics, and function for the enzyme phenylalanine hydroxylase (PAH) can lead to needed new therapies for phenylketonuria, the most common inborn error of amino acid metabolism. PAH is a multidomain homo-multimeric protein whose conformati...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4780608/ https://ncbi.nlm.nih.gov/pubmed/26884182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516967113 |
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