Biophysical characterization of full-length human phenylalanine hydroxylase provides a deeper understanding of its quaternary structure equilibrium

Dysfunction of human phenylalanine hydroxylase (hPAH, EC 1.14.16.1) is the primary cause of phenylketonuria, the most common inborn error of amino acid metabolism. The dynamic domain rearrangements of this multimeric protein have thwarted structural study of the full-length form for decades, until n...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Arturo, Emilia C., Gupta, Kushol, Hansen, Michael R., Borne, Elias, Jaffe, Eileen K.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2019
Subjects:
Molecular Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6664189/
https://ncbi.nlm.nih.gov/pubmed/31076506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008294
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