Biophysical characterization of full-length human phenylalanine hydroxylase provides a deeper understanding of its quaternary structure equilibrium

Dysfunction of human phenylalanine hydroxylase (hPAH, EC 1.14.16.1) is the primary cause of phenylketonuria, the most common inborn error of amino acid metabolism. The dynamic domain rearrangements of this multimeric protein have thwarted structural study of the full-length form for decades, until n...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Arturo, Emilia C., Gupta, Kushol, Hansen, Michael R., Borne, Elias, Jaffe, Eileen K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2019
Konular:
Molecular Biophysics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6664189/
https://ncbi.nlm.nih.gov/pubmed/31076506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008294
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