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First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer

Improved understanding of the relationship among structure, dynamics, and function for the enzyme phenylalanine hydroxylase (PAH) can lead to needed new therapies for phenylketonuria, the most common inborn error of amino acid metabolism. PAH is a multidomain homo-multimeric protein whose conformati...

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Arturo, Emilia C., Gupta, Kushol, Héroux, Annie, Stith, Linda, Cross, Penelope J., Parker, Emily J., Loll, Patrick J., Jaffe, Eileen K.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780608/
https://ncbi.nlm.nih.gov/pubmed/26884182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516967113
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