Structural Biology of Presenilins and Signal Peptide Peptidases

Tekijä Tomita, Taisuke, Iwatsubo, Takeshi
Julkaistu 2013

Extracellular α-synuclein levels are regulated by neuronal activity

Tekijä Yamada, Kaoru, Iwatsubo, Takeshi
Julkaisussa Mol Neurodegener (2018)

The Emerging Functions of LRRK2 and Rab GTPases in the Endolysosomal System

Tekijä Kuwahara, Tomoki, Iwatsubo, Takeshi
Julkaisussa Front Neurosci (2020)

The past, present, and future of disease-modifying therapies for Alzheimer’s disease

Tekijä SUZUKI, Kazushi, IWATA, Atsushi, IWATSUBO, Takeshi
Julkaisussa Proc Jpn Acad Ser B Phys Biol Sci (2017)

Presenilins and γ-Secretase: Structure, Function, and Role in Alzheimer Disease

Tekijä De Strooper, Bart, Iwatsubo, Takeshi, Wolfe, Michael S.
Julkaistu 2012

Presenilin-dependent intramembrane cleavage of ephrin-B1

Tekijä Tomita, Taisuke, Tanaka, Sayaka, Morohashi, Yuichi, Iwatsubo, Takeshi
Julkaistu 2006

Seeded Aggregation and Toxicity of α-Synuclein and Tau: CELLULAR MODELS OF NEURODEGENERATIVE DISEASES

Tekijä Nonaka, Takashi, Watanabe, Sayuri T., Iwatsubo, Takeshi, Hasegawa, Masato
Julkaistu 2010

Contribution of the γ-Secretase Subunits to the Formation of Catalytic Pore of Presenilin 1 Protein

Tekijä Takeo, Koji, Watanabe, Naoto, Tomita, Taisuke, Iwatsubo, Takeshi
Julkaistu 2012

Characterization of the unique In Vitro effects of unsaturated fatty acids on the formation of amyloid β fibrils

Tekijä Eto, Miki, Hashimoto, Tadafumi, Shimizu, Takao, Iwatsubo, Takeshi
Julkaisussa PLoS One (2019)

The C-Terminal PAL Motif and Transmembrane Domain 9 of Presenilin 1 Are Involved in the Formation of the Catalytic Pore of the γ-Secretase

Tekijä Sato, Chihiro, Takagi, Shizuka, Tomita, Taisuke, Iwatsubo, Takeshi
Julkaisussa J Neurosci (2008)

Structure of the Catalytic Pore of γ-Secretase Probed by the Accessibility of Substituted Cysteines

Tekijä Sato, Chihiro, Morohashi, Yuichi, Tomita, Taisuke, Iwatsubo, Takeshi
Julkaisussa J Neurosci (2006)

Phosphorylation of α-Synuclein Protein at Ser-129 Reduces Neuronal Dysfunction by Lowering Its Membrane Binding Property in Caenorhabditis elegans

Tekijä Kuwahara, Tomoki, Tonegawa, Reina, Ito, Genta, Mitani, Shohei, Iwatsubo, Takeshi
Julkaistu 2012

Lack of Correlation between the Kinase Activity of LRRK2 Harboring Kinase-Modifying Mutations and Its Phosphorylation at Ser910, 935, and Ser955

Tekijä Ito, Genta, Fujimoto, Tetta, Kamikawaji, Shogo, Kuwahara, Tomoki, Iwatsubo, Takeshi
Julkaistu 2014

Role of Apolipoprotein E in β-Amyloidogenesis: ISOFORM-SPECIFIC EFFECTS ON PROTOFIBRIL TO FIBRIL CONVERSION OF Aβ IN VITRO AND BRAIN Aβ DEPOSITION IN VIVO

Tekijä Hori, Yukiko, Hashimoto, Tadafumi, Nomoto, Hidetoshi, Hyman, Bradley T., Iwatsubo, Takeshi
Julkaisussa J Biol Chem (2015)

Role of apolipoprotein E in β-amyloidogenesis: Isoform-specific effects on protofibril to fibril conversion of Aβ in vitro and brain Aβ deposition in vivo.

Tekijä Hori, Yukiko, Hashimoto, Tadafumi, Nomoto, Hidetoshi, Hyman, Bradley T., Iwatsubo, Takeshi
Julkaisussa J Biol Chem (2018)

Participation of Transmembrane Domain 1 of Presenilin 1 in the Catalytic Pore Structure of the γ-Secretase

Tekijä Takagi, Shizuka, Tominaga, Aya, Sato, Chihiro, Tomita, Taisuke, Iwatsubo, Takeshi
Julkaisussa J Neurosci (2010)

Imago Mundi, Imago AD, Imago ADNI

Tekijä Villemagne, Victor L, Kim, Seong Yoon, Rowe, Christopher C, Iwatsubo, Takeshi
Julkaisussa Alzheimers Res Ther (2014)

Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production

Tekijä Tominaga, Aya, Cai, Tetsuo, Takagi-Niidome, Shizuka, Iwatsubo, Takeshi, Tomita, Taisuke
Julkaisussa J Neurosci (2016)

Amyloid Angiopathy and Variability in Amyloid β Deposition Is Determined by Mutation Position in Presenilin-1-Linked Alzheimer’s Disease

Tekijä Mann, David M. A., Pickering-Brown, Stuart M., Takeuchi, Ayano, Iwatsubo, Takeshi
Julkaistu 2001

Sample Size Estimation for Alzheimer’s Disease Trials from Japanese ADNI Serial Magnetic Resonance Imaging

Tekijä Fujishima, Motonobu, Kawaguchi, Atsushi, Maikusa, Norihide, Kuwano, Ryozo, Iwatsubo, Takeshi, Matsuda, Hiroshi
Julkaisussa J Alzheimers Dis (2017)