Structural Biology of Presenilins and Signal Peptide Peptidases

Por Tomita, Taisuke, Iwatsubo, Takeshi
Publicado em 2013

Extracellular α-synuclein levels are regulated by neuronal activity

Por Yamada, Kaoru, Iwatsubo, Takeshi
Publicado no Mol Neurodegener (2018)

The Emerging Functions of LRRK2 and Rab GTPases in the Endolysosomal System

Por Kuwahara, Tomoki, Iwatsubo, Takeshi
Publicado no Front Neurosci (2020)

The past, present, and future of disease-modifying therapies for Alzheimer’s disease

Por SUZUKI, Kazushi, IWATA, Atsushi, IWATSUBO, Takeshi
Publicado no Proc Jpn Acad Ser B Phys Biol Sci (2017)

Presenilins and γ-Secretase: Structure, Function, and Role in Alzheimer Disease

Por De Strooper, Bart, Iwatsubo, Takeshi, Wolfe, Michael S.
Publicado em 2012

Presenilin-dependent intramembrane cleavage of ephrin-B1

Por Tomita, Taisuke, Tanaka, Sayaka, Morohashi, Yuichi, Iwatsubo, Takeshi
Publicado em 2006

Seeded Aggregation and Toxicity of α-Synuclein and Tau: CELLULAR MODELS OF NEURODEGENERATIVE DISEASES

Por Nonaka, Takashi, Watanabe, Sayuri T., Iwatsubo, Takeshi, Hasegawa, Masato
Publicado em 2010

Contribution of the γ-Secretase Subunits to the Formation of Catalytic Pore of Presenilin 1 Protein

Por Takeo, Koji, Watanabe, Naoto, Tomita, Taisuke, Iwatsubo, Takeshi
Publicado em 2012

Characterization of the unique In Vitro effects of unsaturated fatty acids on the formation of amyloid β fibrils

Por Eto, Miki, Hashimoto, Tadafumi, Shimizu, Takao, Iwatsubo, Takeshi
Publicado no PLoS One (2019)

The C-Terminal PAL Motif and Transmembrane Domain 9 of Presenilin 1 Are Involved in the Formation of the Catalytic Pore of the γ-Secretase

Por Sato, Chihiro, Takagi, Shizuka, Tomita, Taisuke, Iwatsubo, Takeshi
Publicado no J Neurosci (2008)

Structure of the Catalytic Pore of γ-Secretase Probed by the Accessibility of Substituted Cysteines

Por Sato, Chihiro, Morohashi, Yuichi, Tomita, Taisuke, Iwatsubo, Takeshi
Publicado no J Neurosci (2006)

Phosphorylation of α-Synuclein Protein at Ser-129 Reduces Neuronal Dysfunction by Lowering Its Membrane Binding Property in Caenorhabditis elegans

Por Kuwahara, Tomoki, Tonegawa, Reina, Ito, Genta, Mitani, Shohei, Iwatsubo, Takeshi
Publicado em 2012

Lack of Correlation between the Kinase Activity of LRRK2 Harboring Kinase-Modifying Mutations and Its Phosphorylation at Ser910, 935, and Ser955

Por Ito, Genta, Fujimoto, Tetta, Kamikawaji, Shogo, Kuwahara, Tomoki, Iwatsubo, Takeshi
Publicado em 2014

Role of Apolipoprotein E in β-Amyloidogenesis: ISOFORM-SPECIFIC EFFECTS ON PROTOFIBRIL TO FIBRIL CONVERSION OF Aβ IN VITRO AND BRAIN Aβ DEPOSITION IN VIVO

Por Hori, Yukiko, Hashimoto, Tadafumi, Nomoto, Hidetoshi, Hyman, Bradley T., Iwatsubo, Takeshi
Publicado no J Biol Chem (2015)

Role of apolipoprotein E in β-amyloidogenesis: Isoform-specific effects on protofibril to fibril conversion of Aβ in vitro and brain Aβ deposition in vivo.

Por Hori, Yukiko, Hashimoto, Tadafumi, Nomoto, Hidetoshi, Hyman, Bradley T., Iwatsubo, Takeshi
Publicado no J Biol Chem (2018)

Participation of Transmembrane Domain 1 of Presenilin 1 in the Catalytic Pore Structure of the γ-Secretase

Por Takagi, Shizuka, Tominaga, Aya, Sato, Chihiro, Tomita, Taisuke, Iwatsubo, Takeshi
Publicado no J Neurosci (2010)

Imago Mundi, Imago AD, Imago ADNI

Por Villemagne, Victor L, Kim, Seong Yoon, Rowe, Christopher C, Iwatsubo, Takeshi
Publicado no Alzheimers Res Ther (2014)

Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production

Por Tominaga, Aya, Cai, Tetsuo, Takagi-Niidome, Shizuka, Iwatsubo, Takeshi, Tomita, Taisuke
Publicado no J Neurosci (2016)

Amyloid Angiopathy and Variability in Amyloid β Deposition Is Determined by Mutation Position in Presenilin-1-Linked Alzheimer’s Disease

Por Mann, David M. A., Pickering-Brown, Stuart M., Takeuchi, Ayano, Iwatsubo, Takeshi
Publicado em 2001

Sample Size Estimation for Alzheimer’s Disease Trials from Japanese ADNI Serial Magnetic Resonance Imaging

Por Fujishima, Motonobu, Kawaguchi, Atsushi, Maikusa, Norihide, Kuwano, Ryozo, Iwatsubo, Takeshi, Matsuda, Hiroshi
Publicado no J Alzheimers Dis (2017)