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Structural Biology of Presenilins and Signal Peptide Peptidases
Presenilin and signal peptide peptidase are multispanning intramembrane-cleaving proteases with a conserved catalytic GxGD motif. Presenilin comprises the catalytic subunit of γ-secretase, a protease responsible for the generation of amyloid-β peptides causative of Alzheimer disease. Signal peptide...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3663492/ https://ncbi.nlm.nih.gov/pubmed/23585568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R113.463281 |
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