Three-dimensional Structure of the Signal Peptide Peptidase

Signal peptide peptidase (SPP) is an atypical aspartic protease that hydrolyzes peptide bonds within the transmembrane domain of substrates and is implicated in several biological and pathological functions. Here, we analyzed the structure of human SPP by electron microscopy and reconstructed the th...

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Hauptverfasser: Miyashita(宮, Hiroyuki, 下紘幸), Maruyama(丸, Yuusuke, 山雄介), Isshiki(一, Hayato, 色隼人), Osawa(大, Satoko, 沢智子), Ogura(小, Toshihiko, 椋俊彦), Mio(三, Kazuhiro, 尾和弘), Sato(佐, Chikara, 藤主税), Tomita(富, Taisuke, 田泰輔), Iwatsubo(岩, Takeshi, 坪威)
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138278/
https://ncbi.nlm.nih.gov/pubmed/21636854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.260273
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