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Presenilins and γ-Secretase: Structure, Function, and Role in Alzheimer Disease
Presenilins were first discovered as sites of missense mutations responsible for early-onset Alzheimer disease (AD). The encoded multipass membrane proteins were subsequently found to be the catalytic components of γ-secretases, membrane-embedded aspartyl protease complexes responsible for generatin...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3253024/ https://ncbi.nlm.nih.gov/pubmed/22315713 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a006304 |
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