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Presenilins and γ-Secretase: Structure, Function, and Role in Alzheimer Disease

Presenilins were first discovered as sites of missense mutations responsible for early-onset Alzheimer disease (AD). The encoded multipass membrane proteins were subsequently found to be the catalytic components of γ-secretases, membrane-embedded aspartyl protease complexes responsible for generatin...

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Detalhes bibliográficos
Main Authors: De Strooper, Bart, Iwatsubo, Takeshi, Wolfe, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253024/
https://ncbi.nlm.nih.gov/pubmed/22315713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a006304
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