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Structure, Mechanism and Inhibition of γ-Secretase and Presenilin-Like Proteases
Presenilin is the catalytic component of γ-secretase, a complex aspartyl protease and a founding member of intramembrane-cleaving proteases. γ-Secretase is involved in the pathogenesis of Alzheimer’s disease and a top target for therapeutic intervention. However, the protease complex processes a var...
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2997569/ https://ncbi.nlm.nih.gov/pubmed/20482315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1515/BC.2010.086 |
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