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Inhibition of γ-Secretase Leads to an Increase in Presenilin-1
γ-Secretase inhibitors (GSIs) are potential therapeutic agents for Alzheimer’s disease (AD); however, trials have proven disappointing. We addressed the possibility that γ-secretase inhibition can provoke a rebound effect, elevating the levels of the catalytic γ-secretase subunit, presenilin-1 (PS1)...
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| Publicado no: | Mol Neurobiol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5948247/ https://ncbi.nlm.nih.gov/pubmed/28815510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-017-0705-1 |
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