Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease

Eitemau Tebyg

• Putting presenilins centre stage. Introduction to the Talking Point on the role of presenilin mutations in Alzheimer disease
  gan: Hardy, John
  Cyhoeddwyd: (2007)
• When loss is gain: reduced presenilin proteolytic function leads to increased Aβ42/Aβ40. Talking Point on the role of presenilin mutations in Alzheimer disease
  gan: Wolfe, Michael S
  Cyhoeddwyd: (2007)
• Presenilins and γ-Secretase: Structure, Function, and Role in Alzheimer Disease
  gan: De Strooper, Bart, et al.
  Cyhoeddwyd: (2012)
• Familial Alzheimer disease–linked mutations specifically disrupt Ca(2+) leak function of presenilin 1
  gan: Nelson, Omar, et al.
  Cyhoeddwyd: (2007)
• Presenilins Form ER Ca(2+) Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations
  gan: Tu, Huiping, et al.
  Cyhoeddwyd: (2006)