Structural Biology of Presenilins and Signal Peptide Peptidases

von Tomita, Taisuke, Iwatsubo, Takeshi
Veröffentlicht 2013

Extracellular α-synuclein levels are regulated by neuronal activity

von Yamada, Kaoru, Iwatsubo, Takeshi
Veröffentlicht in Mol Neurodegener (2018)

The Emerging Functions of LRRK2 and Rab GTPases in the Endolysosomal System

von Kuwahara, Tomoki, Iwatsubo, Takeshi
Veröffentlicht in Front Neurosci (2020)

The past, present, and future of disease-modifying therapies for Alzheimer’s disease

von SUZUKI, Kazushi, IWATA, Atsushi, IWATSUBO, Takeshi
Veröffentlicht in Proc Jpn Acad Ser B Phys Biol Sci (2017)

Presenilins and γ-Secretase: Structure, Function, and Role in Alzheimer Disease

von De Strooper, Bart, Iwatsubo, Takeshi, Wolfe, Michael S.
Veröffentlicht 2012

Presenilin-dependent intramembrane cleavage of ephrin-B1

von Tomita, Taisuke, Tanaka, Sayaka, Morohashi, Yuichi, Iwatsubo, Takeshi
Veröffentlicht 2006

Seeded Aggregation and Toxicity of α-Synuclein and Tau: CELLULAR MODELS OF NEURODEGENERATIVE DISEASES

von Nonaka, Takashi, Watanabe, Sayuri T., Iwatsubo, Takeshi, Hasegawa, Masato
Veröffentlicht 2010

Contribution of the γ-Secretase Subunits to the Formation of Catalytic Pore of Presenilin 1 Protein

von Takeo, Koji, Watanabe, Naoto, Tomita, Taisuke, Iwatsubo, Takeshi
Veröffentlicht 2012

Characterization of the unique In Vitro effects of unsaturated fatty acids on the formation of amyloid β fibrils

von Eto, Miki, Hashimoto, Tadafumi, Shimizu, Takao, Iwatsubo, Takeshi
Veröffentlicht in PLoS One (2019)

The C-Terminal PAL Motif and Transmembrane Domain 9 of Presenilin 1 Are Involved in the Formation of the Catalytic Pore of the γ-Secretase

von Sato, Chihiro, Takagi, Shizuka, Tomita, Taisuke, Iwatsubo, Takeshi
Veröffentlicht in J Neurosci (2008)

Structure of the Catalytic Pore of γ-Secretase Probed by the Accessibility of Substituted Cysteines

von Sato, Chihiro, Morohashi, Yuichi, Tomita, Taisuke, Iwatsubo, Takeshi
Veröffentlicht in J Neurosci (2006)

Phosphorylation of α-Synuclein Protein at Ser-129 Reduces Neuronal Dysfunction by Lowering Its Membrane Binding Property in Caenorhabditis elegans

von Kuwahara, Tomoki, Tonegawa, Reina, Ito, Genta, Mitani, Shohei, Iwatsubo, Takeshi
Veröffentlicht 2012

Lack of Correlation between the Kinase Activity of LRRK2 Harboring Kinase-Modifying Mutations and Its Phosphorylation at Ser910, 935, and Ser955

von Ito, Genta, Fujimoto, Tetta, Kamikawaji, Shogo, Kuwahara, Tomoki, Iwatsubo, Takeshi
Veröffentlicht 2014

Role of Apolipoprotein E in β-Amyloidogenesis: ISOFORM-SPECIFIC EFFECTS ON PROTOFIBRIL TO FIBRIL CONVERSION OF Aβ IN VITRO AND BRAIN Aβ DEPOSITION IN VIVO

von Hori, Yukiko, Hashimoto, Tadafumi, Nomoto, Hidetoshi, Hyman, Bradley T., Iwatsubo, Takeshi
Veröffentlicht in J Biol Chem (2015)

Role of apolipoprotein E in β-amyloidogenesis: Isoform-specific effects on protofibril to fibril conversion of Aβ in vitro and brain Aβ deposition in vivo.

von Hori, Yukiko, Hashimoto, Tadafumi, Nomoto, Hidetoshi, Hyman, Bradley T., Iwatsubo, Takeshi
Veröffentlicht in J Biol Chem (2018)

Participation of Transmembrane Domain 1 of Presenilin 1 in the Catalytic Pore Structure of the γ-Secretase

von Takagi, Shizuka, Tominaga, Aya, Sato, Chihiro, Tomita, Taisuke, Iwatsubo, Takeshi
Veröffentlicht in J Neurosci (2010)

Imago Mundi, Imago AD, Imago ADNI

von Villemagne, Victor L, Kim, Seong Yoon, Rowe, Christopher C, Iwatsubo, Takeshi
Veröffentlicht in Alzheimers Res Ther (2014)

Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production

von Tominaga, Aya, Cai, Tetsuo, Takagi-Niidome, Shizuka, Iwatsubo, Takeshi, Tomita, Taisuke
Veröffentlicht in J Neurosci (2016)

Amyloid Angiopathy and Variability in Amyloid β Deposition Is Determined by Mutation Position in Presenilin-1-Linked Alzheimer’s Disease

von Mann, David M. A., Pickering-Brown, Stuart M., Takeuchi, Ayano, Iwatsubo, Takeshi
Veröffentlicht 2001

Sample Size Estimation for Alzheimer’s Disease Trials from Japanese ADNI Serial Magnetic Resonance Imaging

von Fujishima, Motonobu, Kawaguchi, Atsushi, Maikusa, Norihide, Kuwano, Ryozo, Iwatsubo, Takeshi, Matsuda, Hiroshi
Veröffentlicht in J Alzheimers Dis (2017)