Pizotifen Activates ERK and Provides Neuroprotection in vitro and in vivo in Models of Huntington’s Disease

por Sarantos, Melissa R., Papanikolaou, Theodora, Ellerby, Lisa M., Hughes, Robert E.
Publicado em 2012

DEPTOR Is a Stemness Factor That Regulates Pluripotency of Embryonic Stem Cells

por Agrawal, Pooja, Reynolds, Joseph, Chew, Shereen, Lamba, Deepak A., Hughes, Robert E.
Publicado no J Biol Chem (2014)

Mutant Huntingtin Alters Cell Fate in Response to Microtubule Depolymerization via the GEF-H1-RhoA-ERK Pathway

por Varma, Hemant, Yamamoto, Ai, Sarantos, Melissa R., Hughes, Robert E., Stockwell, Brent R.
Publicado em 2010

Ubiquitin-specific Peptidase 9, X-linked (USP9X) Modulates Activity of Mammalian Target of Rapamycin (mTOR)

por Agrawal, Pooja, Chen, Yu-Ting, Schilling, Birgit, Gibson, Bradford W., Hughes, Robert E.
Publicado em 2012

Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR).

por Agrawal, Pooja, Chen, Yu-Ting, Schilling, Birgit, Gibson, Bradford W., Hughes, Robert E.
Publicado em 2014

A Protein Interaction Network for Ecm29 Links the 26 S Proteasome to Molecular Motors and Endosomal Components

por Gorbea, Carlos, Pratt, Gregory, Ustrell, Vicença, Bell, Russell, Sahasrabudhe, Sudhir, Hughes, Robert E., Rechsteiner, Martin
Publicado em 2010

Genomic Analysis of ATP Efflux in Saccharomyces cerevisiae

por Peters, Theodore W., Miller, Aaron W., Tourette, Cendrine, Agren, Hannah, Hubbard, Alan, Hughes, Robert E.
Publicado no G3 (Bethesda) (2015)

Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening

por Orr, Adam L., Ashok, Deepthi, Sarantos, Melissa R., Shi, Tong, Hughes, Robert E., Brand, Martin D.
Publicado no Free Radic Biol Med (2013)

A Large Scale Huntingtin Protein Interaction Network Implicates Rho GTPase Signaling Pathways in Huntington Disease

por Tourette, Cendrine, Li, Biao, Bell, Russell, O'Hare, Shannon, Kaltenbach, Linda S., Mooney, Sean D., Hughes, Robert E.
Publicado em 2014

Altered transcription in yeast expressing expanded polyglutamine

por Hughes, Robert E., Lo, Russell S., Davis, Colleen, Strand, Andrew D., Neal, Cassandra L., Olson, James M., Fields, Stanley
Publicado em 2001

Interaction of an atypical Plasmodium falciparum ETRAMP with human apolipoproteins

por Vignali, Marissa, McKinlay, Anastasia, LaCount, Douglas J, Chettier, Rakesh, Bell, Russell, Sahasrabudhe, Sudhir, Hughes, Robert E, Fields, Stanley
Publicado em 2008

Novel Inhibitors of Mitochondrial sn-Glycerol 3-phosphate Dehydrogenase

por Orr, Adam L., Ashok, Deepthi, Sarantos, Melissa R., Ng, Ryan, Shi, Tong, Gerencser, Akos A., Hughes, Robert E., Brand, Martin D.
Publicado em 2014

A Human Protein Interaction Network Shows Conservation of Aging Processes between Human and Invertebrate Species

por Bell, Russell, Hubbard, Alan, Chettier, Rakesh, Chen, Di, Miller, John P., Kapahi, Pankaj, Tarnopolsky, Mark, Sahasrabuhde, Sudhir, Melov, Simon, Hughes, Robert E.
Publicado em 2009

Natural Genetic Variation in Yeast Reveals That NEDD4 Is a Conserved Modifier of Mutant Polyglutamine Aggregation

por Peters, Theodore W., Nelson, Christopher S., Gerencser, Akos A., Dumas, Kathleen J., Tavshanjian, Brandon, Chang, Kyu Chul, Lithgow, Gordon J., Hughes, Robert E.
Publicado no G3 (Bethesda) (2018)

Chemical activation of a food deprivation signal extends lifespan

por Lucanic, Mark, Garrett, Theo, Yu, Ivan, Calahorro, Fernando, Asadi Shahmirzadi, Azar, Miller, Aaron, Gill, Matthew S., Hughes, Robert E., Holden‐Dye, Lindy, Lithgow, Gordon J.
Publicado no Aging Cell (2016)

Tor1 regulates protein solubility in Saccharomyces cerevisiae

por Peters, Theodore W., Rardin, Matthew J., Czerwieniec, Gregg, Evani, Uday S., Reis-Rodrigues, Pedro, Lithgow, Gordon J., Mooney, Sean D., Gibson, Bradford W., Hughes, Robert E.
Publicado em 2012

Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan

por Reis-Rodrigues, Pedro, Czerwieniec, Gregg, Peters, Theodore W, Evani, Uday S, Alavez, Silvestre, Gaman, Emily A, Vantipalli, Maithili, Mooney, Sean D, Gibson, Bradford W, Lithgow, Gordon J, Hughes, Robert E
Publicado em 2012

Matrix Metalloproteinases are Modifiers of Huntingtin Proteolysis and Toxicity in Huntington’s Disease

por Miller, John P., Holcomb, Jennifer, Al-Ramahi, Ismael, de Haro, Maria, Gafni, Juliette, Zhang, Ningzhe, Kim, Eugene, Sanhueza, Mario, Torcassi, Cameron, Kwak, Seung, Botas, Juan, Hughes, Robert E., Ellerby, Lisa M.
Publicado em 2010

Glucocorticoids Suppress Selected Components of the Senescence-Associated Secretory Phenotype

por Laberge, Remi-Martin, Zhou, Lili, Sarantos, Melissa R., Rodier, Francis, Freund, Adam, de Keizer, Peter L.J., Liu, Su, Demaria, Marco, Cong, Yu-Sheng, Kapahi, Pankaj, Desprez, Pierre-Yves, Hughes, Robert E., Campisi, Judith
Publicado em 2012

A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease

por Miller, John P., Yates, Bridget E., Al-Ramahi, Ismael, Berman, Ari E., Sanhueza, Mario, Kim, Eugene, de Haro, Maria, DeGiacomo, Francesco, Torcassi, Cameron, Holcomb, Jennifer, Gafni, Juliette, Mooney, Sean D., Botas, Juan, Ellerby, Lisa M., Hughes, Robert E.
Publicado em 2012