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Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening

Mitochondrial production of reactive oxygen species is often considered an unavoidable consequence of aerobic metabolism and currently cannot be manipulated without perturbing oxidative phosphorylation. Antioxidants are widely used to suppress effects of reactive oxygen species after formation, but...

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Détails bibliographiques
Publié dans:Free Radic Biol Med
Auteurs principaux: Orr, Adam L., Ashok, Deepthi, Sarantos, Melissa R., Shi, Tong, Hughes, Robert E., Brand, Martin D.
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321955/
https://ncbi.nlm.nih.gov/pubmed/23994103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.08.170
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