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Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening

Mitochondrial production of reactive oxygen species is often considered an unavoidable consequence of aerobic metabolism and currently cannot be manipulated without perturbing oxidative phosphorylation. Antioxidants are widely used to suppress effects of reactive oxygen species after formation, but...

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Foilsithe in:Free Radic Biol Med
Main Authors: Orr, Adam L., Ashok, Deepthi, Sarantos, Melissa R., Shi, Tong, Hughes, Robert E., Brand, Martin D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321955/
https://ncbi.nlm.nih.gov/pubmed/23994103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.08.170
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